Dr. Taixiang Saur (PMHNP)

Education:

• Master of Science in Pharmacology
• Master’s of Science in Nursing – Mental Health
  • MGH Institute of Health Professions
• Doctor of Philosophy (Ph.D.) in Neurobiology & Neurophysics

Clinical Experience:

• Worked and trained within seven different units at McLean Hospital over a course of four years.
• Seven years total clinical mental health experience.
• Worked for ten years in multiple units within a general hospital.
• Well versed in treating patients with a variety of mental illnesses listed below as well as other mental illnesses:
  • Psychotic disorders
  • Mood disorders
  • Anxiety disorders
  • Trauma related disorders
  • Personality disorders
  • Somatic disorders
  • ADHD
  • Dual diagnosis

Other Experience:

• Treatments include psychopharmacology and psychotherapy, cognitive behavioral therapy, dialectical behavior therapy and others.
• Researcher at Harvard Medical School & McLean Hospital, studied areas of neurobiology, neuropharmacology, neuropsychiatry, neurogenetics, neurophysics.
• Authored 13 Peer-reviewed articles published in prestigious journals. (see Publications listed below)

• MS in Pharmacology
• MSN in Nursing
• PHD in Neurobiology/Neurophysics

Peer-Reviewed Publications

(Note previous last name was Xu)

1. Saur T, Peng IF, Jiang P, Gong N, Yao WD, Xu TL, Wu CF. K⁺ channel reorganization and homeostatic plasticity during postembryonic development: biophysical and genetic analyses in acutely dissociated Drosophila central neurons. J Neurogenet. 2016; 30(3-4):259-275.

2. Wang X, Hao L, Saur T, Joyal K, Zhao Y, Zhai D, Li J, Pribadi M, Coppola G, Cohen BM, Buttner EA. Forward genetic screen in Caenorhabditis elegans suggests F57A10.2/VAMP and acp-4/ACP2 as suppressors of C9ORF72 related phenotypes. Front Mol Neurosci. 2016, 8; 9:113. eCollection.

3. Saur T, Cohen BM, Ma Q, Babb SM, Buttner EA, Yao WD. Acute and chronic effects of clozapi… on cholinergic transmission in cultured mouse superior cervical ganglion neurons. J Neurogenet. 2016; 30(3-4):297-305.

4. Ruan H, Saur T and Yao WD. Dopamine-enabled anti-Hebbian timing-dependent plasticity in prefrontal circuitry. Front Neural Circuits. 2014; 8:38. doi: 10.3389/fncir.2014.00038. eCollection. (Co-first author)

5. Zhang J, Saur T, Duke AN, Cooper O, Isacson O, Rowlett JK, and Yao WD. Motor impairments, striatal degeneration, and altered dopamine-glutamate interaction in mice lacking PSD-95. Journal of Neurogenetics. 2014; 28(1-2):98-111. (Co-first author)

6. Saur T, DeMarco SE, Ortiz A, Sliwoski GR, Hao L, Wang X, Cohen BM, Buttner EA. A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target. Plos Genetics. 2013;9(2):e1003313.

7. Xu TX, Ma Q, Spealman RD, Yao WD. Amphetami… modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant. Journal of Neurochemistry. 2010;115(6):1643-1654.

8. Xu TX, Yao WD. D1 and D2 dopamine receptors in separate circuits cooperate to drive associative long-term potentiation in the prefrontal cortex. Proceedings of the National Academy of Sciences. U S A. 2010; 107(37):16366-16371.

9. Xu TX, Sotnikova TD, Liang C, Zhang J, Jung JU, Spealman RD, Gainetdinov RR, Yao WD. Hyperdopaminergic tone erodes prefrontal LTP via a D2 receptor-operated protein phosphatase gate. The Journal of Neuroscience. 2009; 29(45):14086-14099.

10. Zhang J, Xu TX, Hallett PJ, Watanabe M, Grant SGN, Isacson O, Yao WD. PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex. The Journal of Neuroscience. 2009; 29(9):2948-2960.

11. Xu TX, Gong N, Xu TL. Divalent cation modulation of A-type potassium channels in acutely dissociated Drosophila central neurons. Journal of Neurogenetics. 2005; 19(2):87-107.

12. Xu TX, Gong N, Xu TL. Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission. NeuroReport. 2005; 16(11):1227-1231.

13. Xu TX, Lu H, Wang Q, Wu LJ, Liu J, Zhou Z, Xu TL. Properties of whole-cell potassium currents in mechanically dissociated Drosophila larval central neuron. Acta Physiologica sinica. 2002; 54(5): 411-416.